{"id":518,"date":"2024-07-09T03:57:32","date_gmt":"2024-07-09T09:57:32","guid":{"rendered":"http:\/\/anc.local\/?page_id=518"},"modified":"2024-07-09T04:00:21","modified_gmt":"2024-07-09T10:00:21","slug":"bruno-lomonte-vigliotti","status":"publish","type":"page","link":"https:\/\/www.anc.cr\/en\/bruno-lomonte-vigliotti\/","title":{"rendered":"Bruno Lomonte Vigliotti"},"content":{"rendered":"
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Bruno Lomonte Vigliotti<\/h2>\n\n\n\n

Acad\u00e9mico de N\u00famero<\/p>\n\n\n\n

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  • Catedr\u00e1tico, Instituto Clodomiro Picado, Universidad de Costa Rica, San Jos\u00e9, Costa Rica.<\/li>\n\n\n\n
  • Lic. en Microbiolog\u00eda y Qu\u00edmica Cl\u00ednica, Universidad de Costa Rica (1981).<\/li>\n\n\n\n
  • M.Sc., Microbiolog\u00eda e Inmunolog\u00eda, Universidad de Costa Rica (1986).<\/li>\n\n\n\n
  • Fulbright Research Scholar, Universidad de Wisconsin-Madison, EUA (1987).<\/li>\n\n\n\n
  • Ph.D., Departamento de Inmunolog\u00eda Cl\u00ednica, Universidad de G\u00f6teborg, Suecia (1994).<\/li>\n<\/ul>\n<\/div>\n\n\n\n
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    Bruno Lomonte ha estudiado las caracter\u00edsticas inmunol\u00f3gicas y bioqu\u00edmicas de los venenos de serpientes de Costa Rica y sus toxinas. Sus investigaciones se han enfocado principalmente en la caracterizaci\u00f3n de un grupo de fosfolipasas A2 que da\u00f1an las c\u00e9lulas musculares (miotoxinas), y en la b\u00fasqueda y estudio de inhibidores para estas toxinas. Tambi\u00e9n, se interesa en la seroterapia antiof\u00eddica y la preparaci\u00f3n de anticuerpos policlonales y monoclonales contra toxinas, las aplicaciones de los p\u00e9ptidos sint\u00e9ticos, y el desarrollo de inmunoensayos. M\u00e1s recientemente, se agrega a sus intereses de investigaci\u00f3n la aplicaci\u00f3n de t\u00e9cnicas de an\u00e1lisis prote\u00f3mico mediante espectrometr\u00eda de masas. Ha dirigido 32 tesis de grado y posgrado a lo largo de cuatro d\u00e9cadas de trabajo en el Instituto Clodomiro Picado (Facultad de Microbiolog\u00eda) de la UCR, en donde es actualmente Profesor Em\u00e9rito.<\/p>\n

    Ha ocupado cargos como Director del Programa de Maestr\u00eda en Microbiolog\u00eda, y Director (fundador) del Programa de Doctorado en Ciencias de la UCR. Su producci\u00f3n cient\u00edfica incluye m\u00e1s de 360 publicaciones en revistas especializadas y libros. Es miembro de la Academia Nacional de Ciencias de Costa Rica y de la International Society on Toxinology. Ha recibido el Premio Nacional de Ciencias (1986), el Premio King Baudouin de la International Foundation for Science (1994), el Premio TWAS-CONICIT en Ciencias Biol\u00f3gicas (1997), el Premio al Investigador de la Universidad de Costa Rica en Ciencias de la Salud (2010), y el Redi Award de la International Society on Toxinology (2022).<\/p>\n\n\n\n\n

    Publicaciones representativas<\/h3>\n\n\n\n
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    • Lomonte B, Kahan L (1988) Production and partial characterization of monoclonal antibodies to Bothrops asper (terciopelo) myotoxin. Toxicon 26, 675.<\/li>\n\n\n\n
    • Lomonte B, Moreno E, Tarkowski A, Hanson L\u00c5, Maccarana M (1994) Neutralizing interaction between heparins and myotoxin II, a Lys-49 phospholipase A2 from Bothrops asper snake venom. Identification of a heparin-binding and cytolytic toxin region by the use of synthetic peptides and molecular modeling. Journal of Biological Chemistry 269, 29867.<\/li>\n\n\n\n
    • Lomonte B, Angulo Y, Santamar\u00eda C (2003) Comparative study of synthetic peptides corresponding to region 115-129 in Lys49 myotoxic phospholipases A2 from snake venoms. Toxicon 42, 307-312.<\/li>\n\n\n\n
    • Cintra-Francischinelli M, Caccin P, Chiavegato A, Pizzo P, Carmignoto G, Angulo Y, Lomonte B, Guti\u00e9rrez JM, Montecucco C (2010) Bothrops snake myotoxins induce a large efflux of ATP and potassium with spreading of cell damage and pain. Proceedings of the National Academy of Sciences USA 107, 14140-14145.<\/li>\n\n\n\n
    • Lomonte B, Fern\u00e1ndez J, Sanz L, Angulo Y, Sasa M, Guti\u00e9rrez JM, Calvete JJ (2014) Venomous snakes of Costa Rica: biological and medical implications of their venom proteomic profiles analyzed through the strategy of “snake venomics”. Journal of Proteomics 105, 323-339.<\/li>\n\n\n\n
    • Lomonte B, Rey-Su\u00e1rez P, Fern\u00e1ndez J, Sasa M, Pla D, Vargas N, B\u00e9nard-Valle M, Sanz L, Corr\u00eaa-Netto C, N\u00fa\u00f1ez V, Alape-Gir\u00f3n A, Alag\u00f3n A, Guti\u00e9rrez JM, Calvete JJ (2016) Venoms of Micrurus coral snakes: evolutionary trends in compositional patterns emerging from proteomic analyses. Toxicon 122, 7-25.<\/li>\n\n\n\n
    • Massimino ML, Simonato M, Spolaore B, Franchin C, Arrigoni G, Marin O, Monturiol-Gross L, Fern\u00e1ndez J, Lomonte B, Tonello F (2018) Cell surface nucleolin interacts with and internalizes Bothrops asper Lys49 phospholipase A2 and mediates its toxic activity. Scientific Reports 8, 10619.<\/li>\n\n\n\n
    • Laustsen AH, Karatt-Vellatt A, Masters EW, Arias AS, Pu\u0161 U, Knudsen C, Oscoz S, Slavny P, Griffiths DT, Luther AM, Leah RA, Lindholm M, Lomonte B, Gutie\u0301rrez JM, McCafferty J (2018) In vivo neutralization of the dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG monoclonal antibodies. Nature Communications 9, 3928.<\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"

      Bruno Lomonte Vigliotti Acad\u00e9mico de N\u00famero Bruno Lomonte ha estudiado las caracter\u00edsticas inmunol\u00f3gicas y bioqu\u00edmicas de los venenos de serpientes de Costa Rica y sus toxinas. Sus investigaciones se han enfocado principalmente en la caracterizaci\u00f3n de un grupo de fosfolipasas A2 que da\u00f1an las c\u00e9lulas musculares (miotoxinas), y en la b\u00fasqueda y estudio de inhibidores […]<\/p>\n","protected":false},"author":1,"featured_media":471,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-518","page","type-page","status-publish","has-post-thumbnail","hentry"],"yoast_head":"\nBruno Lomonte Vigliotti - ANC<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.anc.cr\/en\/bruno-lomonte-vigliotti\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Bruno Lomonte Vigliotti - ANC\" \/>\n<meta property=\"og:description\" content=\"Bruno Lomonte Vigliotti Acad\u00e9mico de N\u00famero Bruno Lomonte ha estudiado las caracter\u00edsticas inmunol\u00f3gicas y bioqu\u00edmicas de los venenos de serpientes de Costa Rica y sus toxinas. 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